KLOW

Description

KLOW is a research-grade peptide blend developed by Synova Supply, combining four extensively studied compounds — GHK-Cu (Copper Tripeptide-1), BPC-157 (Body Protection Compound), TB-500 (Thymosin Beta-4 Fragment), and KPV (Lysine-Proline-Valine) — in a single lyophilized formulation.

GHK-Cu (Copper Tripeptide-1) is a naturally occurring human plasma tripeptide with high affinity for copper ions. Preclinical research has extensively examined its role in extracellular matrix remodeling, collagen and elastin synthesis in fibroblast cell cultures, matrix metalloproteinase regulation, wound repair signaling, and antioxidant enzyme activity. Gene expression studies have reported its influence on a broad range of genes associated with inflammation resolution, DNA repair, and cellular stress response pathways.

BPC-157 (Body Protection Compound) is a synthetic pentadecapeptide comprising 15 amino acids. It has been the subject of extensive preclinical research examining its role in musculoskeletal tissue repair, tendon-to-bone healing mechanisms, angiogenesis, and gastrointestinal mucosal regeneration in animal models. Its interaction with growth hormone receptor pathways and nitric oxide signaling has also been a subject of published in-vitro literature.

TB-500 (Thymosin Beta-4 Fragment) is a synthetic analogue derived from the actin-sequestering domain of Thymosin Beta-4. Research interest centers on its role in cell migration, proliferation, and new blood vessel formation. Preclinical studies have examined TB-500 in the context of wound healing, skeletal muscle repair, cardiac tissue recovery, and inflammatory response modulation across multiple animal model systems.

KPV (Lysine-Proline-Valine) is a C-terminal tripeptide fragment of alpha-melanocyte stimulating hormone (α-MSH), specifically the final three amino acids of the native peptide sequence. It has been studied as the primary anti-inflammatory active fragment of α-MSH, with preclinical research examining its activity at melanocortin receptors — particularly MC1R and MC3R — and its downstream effects on NF-κB signaling inhibition and pro-inflammatory cytokine suppression. In vitro studies have investigated its effects on intestinal epithelial cell inflammation models, macrophage activation, and oxidative stress markers. Its small size and demonstrated cell-penetrating properties in preclinical models have made it a subject of interest in mucosal and gastrointestinal inflammation research.

As a combined formulation, KLOW provides researchers with a single reagent for studying the overlapping and potentially complementary signaling pathways associated with these four peptide compounds across tissue repair, extracellular matrix remodeling, cell migration, and inflammatory response research contexts.

Supplied as: Lyophilized powder, sealed vial Purity: ≥99% (HPLC verified per batch) Testing: Independent third-party mass spectrometry and HPLC Origin: United States Storage: −20°C, protected from light and moisture Reconstitution: Bacteriostatic water (not included)

For research use only. Not for human or animal administration. Must be handled by a qualified researcher in a licensed laboratory setting. This product is not approved by the FDA and is not intended for diagnostic or therapeutic use.